One-Day Course
Sunday, November 16; 8:30am – 5:00pm
Larry Miller, Novartis, Cambridge, MA
J. David Pinkston, SuperSep Consulting, LLC, Decatur, IL
COURSE DESCRIPTION
This course will focus on fundamentals and advances in supercritical fluid chromatography (SFC) employing carbon dioxide-based mobile phases. Emphasis will be directed toward pharmaceuticals and will touch on other fields where SFC currently plays or will play a critical role such as lipidomics, specialty chemicals and polymers, biodiesel, foods and vitamins, natural products, and flavors/fragrances. Example applications in these areas will be used throughout the course as teaching illustrations.
WHO SHOULD ATTEND
Anyone currently using GC, HPLC or other chromatographic techniques for analysis and/or purification and interested in learning how SFC can increase efficiency while reducing costs, or how SFC could be implemented as a complementary, orthogonal technique, will find this course of interest. This includes academic and industrial separation scientists, process chemists, laboratory and R&D managers in the pharmaceutical, specialty chemicals and polymers, food, lipidomics, biodiesel, natural products, flavors/fragrances, materials and medical research industries. Actual experience or knowledge of SFC is not required. Some knowledge of chromatographic principles is desirable.
TOPICS
1. Introduction to Supercritical Fluids and SFC
2. Method Development in Achiral SFC
3. Method Development for Chiral SFC
4. Preparative SFC
Larry Miller is an Associate Director in the Discovery Analytical group at Novartis in Cambridge, MA. He has spent his career performing small molecule achiral and chiral analysis and purifications at the microgram to multi-kg scale. At Novartis, Larry manages a group responsible for analytical and purification support to the Global Discovery Chemistry function. Previously he spent 20 years at Searle/Pharmacia, and 20 years at Amgen. Larry has over 50 peer-reviewed publications and over 45 presentations at scientific meetings and he has served as co-instructor for SFC short courses in the US, Europe, and Asia. He earned his master’s in chemistry from Roosevelt University and his bachelor’s in chemistry from the University of Illinois at Urbana-Champaign.
J. David Pinkston’s primary interests have been supercritical-fluids-based separations, the chemistry of
food/lipids oxidation and preservation, and the analytical chemistry of lipids. After obtaining his
Ph.D. at Michigan State University in analytical chemistry, he began his career at Procter &
Gamble, where he progressed through the technical ranks to Principal Scientist. He later moved to
Kellogg’s Global Chemistry group. His most recent position was Technical Services Manager for
Preservation Systems at Archer Daniels Midland Company. David owns SuperSep Consulting,
LLC. He is on the Governing Board of the American Oil Chemists Society (AOCS) and is past
chair of the AOCS’s Division of Lipid Oxidation and Quality. David is on the Executive Board of
the Green Chemistry Group, and is past chair of the Analytical Division of the ACS. He has taught
as an Adjunct Professor at Virginia Tech, the University of Cincinnati, and Millikin University.
David has taught short courses on supercritical-fluids-based separations dozens of times. He has
authored or co-authored over 60 publications and book chapters, one book, and presented over 130
lectures. When not teaching or consulting, David enjoys traveling, cycling, and downhill skiing.
