Frederick Fiddler, Methrom USA, Riverview, FL

COURSE DESCRIPTION
Titration is widely used for quantitative chemical analysis in the pharmaceutical and personal care industries. Titrations provide vital information for raw material content, active pharmaceutical ingredients (API), intermediates, and final product testing. This Short Course categorizes titrations broadly as; Potentiometric, Karl Fischer and Colorimetric titrations. An introduction is provided to these major categories of titration with an emphasis on electrode selection, method development, troubleshooting, and parameter optimization using case studies. This course will focus on best practices for obtaining accurate and precise titration results by giving an in-depth understanding of the core principles of the aforementioned types of titrations and their optimization. The principles and concepts covered in this course will provide attendees with the ability to optimize existing titrations, apply new approaches where needed and consistently provide titration data that is accurate and precise.

WHO SHOULD ATTEND
This half-day course is ideal for lab chemists, quality control personnel, analytical chemists involved in method development and validation, and managers interested in an in-depth understanding of titration applications and optimization. EAS attendees who are already using automated titrators or are planning to purchase automated titration instruments in the near future will find this class beneficial.

TOPICS
1. Potentiometric Titration and Electrodes
     * Electrodes
        – Potentiometric Electrode theory
        – Electrode selection – Which electrode for which application?
        – Electrode maintenance
     * Potentiometric Titration
        – Basics of potentiometric titration
        – Potentiometric titration curve interpretation
     – Potentiometric titration parameters – What are they and how do they affect titrations?         – Application review – Optimization of methods using real world examples
        – Quality control and troubleshooting

2. Automated Colorimetric Titration 
     * Overview of colorimetric electrode 
     * Real world applications

3. Karl Fischer Titration
     * Karl Fischer titration theory
     * Volumetric Karl Fischer titration (KFV)
        – Application range
        – Reagents
          ^ KFV Reagents
          ^ Solubility Promoters
        – KFV parameters – What are they and how do they affect titrations?
     * Coulometric Karl Fischer titration (KFC)
        – Application range
        – Reagents
          ^ KFC Reagents
          ^ Solubility Promoters
        – KFC parameters – What are they and how do they affect titrations?
     * Karl Fischer analysis for difficult applications
        – KF Oven Technique
        – Homogenization
        – Liquid extraction
     * Quality control and troubleshooting

ABOUT THE INSTRUCTOR
Frederick Fiddler has over thirteen years of experience in analytical chemistry spanning Titrations, Voltammetry, XRF and INAA. For the past 10 years Frederick has worked with the Metrohm group focusing primarily on Titration-related applications, specifically Karl Fischer, Potentiometric and Thermometric titrations across multiple industries. Frederick received his B.Sc in Pure and Applied Chemistry from the University of the West Indies, Jamaica.