One-Day Course
Date to be announce; 8:30am – 5:00pm
Larry Miller, Novartis, Cambridge, MA
COURSE DESCRIPTION
This course will focus on fundamentals and advances in supercritical fluid chromatography (SFC) employing carbon dioxide-based mobile phases. Emphasis will be directed toward pharmaceuticals and will touch on other fields where SFC currently plays or will play a critical role such as lipidomics, specialty chemicals and polymers, biodiesel, foods and vitamins, natural products, and flavors/fragrances. Example applications in these areas will be used throughout the course as teaching illustrations.
WHO SHOULD ATTEND
Anyone currently using GC, HPLC or other chromatographic techniques for analysis and/or purification and interested in learning how SFC can increase efficiency while reducing costs, or how SFC could be implemented as a complementary, orthogonal technique, will find this course of interest. This includes academic and industrial separation scientists, process chemists, laboratory and R&D managers in the pharmaceutical, specialty chemicals and polymers, food, lipidomics, biodiesel, natural products, flavors/fragrances, materials and medical research industries. Actual experience or knowledge of SFC is not required. Some knowledge of chromatographic principles is desirable.
TOPICS
1. Introduction to Supercritical Fluids and SFC
2. Method Development in Achiral SFC
3. Method Development for Chiral SFC
4. Preparative SFC
ABOUT THE INSTRUCTOR
Larry Miller is an Associate Director in the Discovery Analytical group at Novartis in Cambridge, MA. He has spent his career performing small molecule achiral and chiral analysis and purifications at the microgram to multi-kg scale. At Novartis, Larry manages a group responsible for analytical and purification support to the Global Discovery Chemistry function. Previously he spent 20 years at Searle/Pharmacia, and 20 years at Amgen. Larry has over 50 peer-reviewed publications and over 45 presentations at scientific meetings and he has served as co-instructor for SFC short courses in the US, Europe, and Asia. He earned his master’s in chemistry from Roosevelt University and his bachelor’s in chemistry from the University of Illinois at Urbana-Champaign.
