Since 2019, Simone Sidoli is an Assistant Professor at the Department of Biochemistry of the Albert Einstein College of Medicine, and Scientific Director of the Einstein Proteomics Core. His group develops and utilizes biochemical methods mostly based on mass spectrometry (MS) to time-resolve changes in the state, dynamics, and macromolecular interactions of chromatin during aging, cancer, and other conditions.
Dr. Sidoli approached MS as a trainee in the laboratory of Dr. Careri at the University of Parma (Italy), where he established methods to detect protein biomarkers of allergens in food. In 2010, he moved to the University of Southern Denmark (Odense, DK) for his PhD in the group of Dr. Ole N. Jensen, where he developed methods for analyzing the cross-talk between histone post-translational modifications. In 2014, he joined Dr. Benjamin A. Garcia’s lab, located within the Epigenetics Institute at the University of Pennsylvania (Philadelphia, PA, USA). There, he applied his MS methods to link cell signaling cascade (protein phosphorylation) with chromatin changes (histone modifications). These methods include improvements in quantification accuracy of histone codes, enhancement of throughput, quantification of chromatin accessibility and multi-omics data integration. During these years, Dr. Sidoli has been a member of the American Society for Mass Spectrometry (ASMS) and the Human Proteome Organization (HUPO).
To date, Dr. Sidoli co-authored approx. 120 scientific publications, mostly in the field of proteomics and chromatin biology. He received awards like the Umberto Mortari and the Healthy Longevity Grand Challenge. His lab has been funded by the NIH, AFAR, the Leukemia Research Foundation, and the Japan Agency for Medical Research and Development. The research of Dr. Sidoli also receives financial support from the companies Merck, Relay Therapeutics and Deerfield, and non-financial collaboration from CelVivo IVS, Medivac, and Immagina Biotechnology. Finally, Dr. Sidoli’s lab is member of the Einstein Cancer Center, the Nathan Shock Institute for Aging Research, the Einstein-Rockefeller-CUNY Center for AIDS Research and the Einstein Institute for Neuroimmunology and Inflammation.