E22: Practical NMR Spectroscopy

One-Day Course

Date/Time to be announced; 8:30am – 5:00pm

Dr. Damodaran Achary, University of Pittsburgh, Pittsburgh PA

NMR spectroscopy is a powerful analytical tool. There are multitude of techniques suitable for many analytical problems beyond routine 1H/13C spectra. This course will focus on practical skills related to acquiring and interpreting NMR data without hardcore theory/equations. Tips and tricks for acquisition and data processing to get the best out of your spectrometer will be taught. Interpretation of 1D & 2D data to assign functional groups, atom connectivity and structural assignment will be shown. Learn to choosing the right experiments for your problem. Overall, this course will prepare you to engage the spectrometer and analyze NMR data with confidence.

Either you are new to the field, or want to further your understanding of NMR spectroscopy, this is the course that will provide the training for you. It will help gain knowledge in NMR concepts, applications, data processing, spectral analysis, and interpretation. This is for anyone who wants to improve their knowledge in NMR.  Organic/Polymer/Analytical/Bio/Pharmaceutical chemists, material characterization personnel. NMR facility managers, post-docs, grad students, and all newcomers to NMR spectroscopy. This course will also prepare you for the growing need for highly skilled NMR personnel in academia & industry.

  1. Introduction to NMR Spectroscopy
    a. Interactions in NMR spectroscopy and their implications on the NMR spectrum
    b. Multiplicity, spin-spin coupling and patterns
    c. Primer on NMR pulse and sequences
    d. Overview of NMR hardware
  2. 1D NMR Spectroscopy
    a. Anatomy of an FID (Free Induction Decay); signal to noise vs resolution
    b. Factors that affect the quality of the NMR data
    c. Acquisition and Processing techniques; Tips and tricks
    d. Multinuclear NMR experiments
  3. 2D NMR Spectroscopy for Structural Elucidation
    a. Nuts and Bolts of 2D NMR spectroscopy
    b. Homonuclear correlation: COSY, TOCSY, NOESY, ROESY
    c. Heteronuclear correlation: HSQC, HMQC, HMBC
    d. Parameters that influence the quality of 2D NMR data
  4. Advanced 1D and 2D NMR Techniques
    a. Quantitative and Selective NMR experiments
    b, Non-Uniform Sampling (NUS); Increase Resolution & Speed
    c. Pure shift NMR for Ultrahigh resolution 1D and 2D data
    d. Dynamic NMR spectroscopy

Dr. Damodaran Achary received his B.Sc. from the University of Madras, India and his M.Sc. in Physical Chemistry from the University of Pune, India. He received his Ph.D. in Solid State NMR Spectroscopy from the National Chemical Laboratory, India. He then moved to the US for his post-doctoral work at Ames Laboratory, Iowa. Later he took an NMR Spectroscopist/Facility Manager position at Miami University, Oxford, OH. In 2005, he moved to the University of Pittsburgh as the Director of the NMR Facility which he currently holds. His research interests include application of solution and solid-state NMR spectroscopy to interdisciplinary areas of science. He has extensive experience training hundreds of academic and industry users and taught courses on NMR spectroscopy for chemists. He has co-authored over 80 peer-reviewed publications applying NMR spectroscopy to a variety of fields