E21-21: Atomic Spectroscopy in the Pharmaceutical Laboratory

One-Day Course
Monday, Nov. 15; 8:30am – 5:00pm

Dr. Lydia Breckenridge, Bristol-Myers Squibb, New Brunswick, NJ
Dr. Sharla Wood, Bristol-Myers Squibb, New Brunswick, NJ

This course will provide a comprehensive overview of the fundamentals and applications of a variety of analytical techniques that comprise an atomic spectroscopy laboratory, with a specific focus on pharmaceutical applications.  Techniques that will be covered include inductively coupled plasma-mass spectrometry (ICP-MS), inductively coupled plasma-optical emission spectroscopy (ICP-OES), laser ablation-ICP-MS, laser-induced breakdown spectroscopy (LIBS) and X-Ray Fluorescence (XRF).  Applications will include Elemental Impurities testing, foreign matter investigations, routine catalyst remediation assessments and biologic analysis.  Additional emphasis will be on sample preparation techniques and lab set-up.

Scientists interested in expanding their knowledge of analytical techniques, pharmaceutical scientists with an interest in metals analysis, project leaders or quality representatives who may interact with or received data from an atomic spectroscopy lab.

  1. Introduction to Atomic Spectroscopy
  2. A One Hour Segment on each Technique
    a. ICP-MS (Inductively coupled plasma mass spectrometry)
    b. ICP-AES (Inductively coupled plasma atomic emission spectroscopy)
    c. LA-ICP-MS (laser ablation Inductively coupled plasma mass spectrometry)
    d. LIBS (Laser induced breakdown spectroscopy)
    e. XRF (X-ray fluorescence)


Dr. Lydia Breckenridge is a Senior Principal Scientist at Bristol Myers Squibb (BMS) and is the Head of the Atomic Spectroscopy Center of Excellence.  In this position, Lydia leads a group responsible for the testing of inorganic impurities and elemental analysis for the global BMS organization, from early development to commercial manufacturing.  Lydia’s group has significant expertise in a wide variety of Atomic Spectroscopy techniques, including ICP-MS, ICP-OES, XRF, LA and LIBS.  Prior to joining BMS in 2007, Lydia received her Ph.D. from the University of Florida under the direction of Dr. James D. Winefordner, as well as dual MS degrees in Forensic Toxicology and Drug Chemistry, both under the direction of Dr. Ian Tebbitt.  Lydia’s current research interests include applications of laser-based techniques for solid-state elemental pharmaceutical analysis as well as the use of ICP-MS for the assessment of packaging attributes and integrity.

Dr. Sharla Wood received her Ph.D. in Analytical Chemistry from Wayne State University under the advisement of David Rueda and completed a Post-doc at the University of Wisconsin-Madison under the advisement of Randall Goldsmith.  She is currently a Principal Scientist at Bristol Myers Squibb in the Atomic Spectroscopy Center of Excellence where she focuses on elemental analysis in pharmaceutical compounds across the various stages of pharmaceutical development using techniques that include ICP-MS, ICP-OES, laser ablation, and XRF.  Her research interests include the use of solid analysis techniques for metals analysis in pharmaceutical research.